Title: Matching randomly generated proposals to kernels in independence Metropolis chains. Authors: Maarten Marsman, Gunter Maris, Timo Bechger and Cees Glas Affiliation: University of Amsterdam Abstract: A common problem in statistical inference is sampling from not one, but many posterior distributions (say n). This is most convenient when the data are modelled as conditionally independent given the random effects, since then the posterior distributions of the random effects given the data are also conditionally independent. This makes the problem of sampling from the posterior distributions of the random effects ideal for parallel processing. We consider the situation where it is not possible to produce a direct sample from the posterior distribution of any of the n random effects, but where it is easy to generate data from the model. That is, if we consider the factorization of the joint distribution of the parameter and the data then we assume that we are able to generate i.i.d. from both the marginal distribution of the random effects and the conditional distribution of the data. From the composite sample drawn from these two distributions, we obtain a draw from a random posterior distribution (of a random effect). This is not necessarily the posterior distribution that we need a sample from. An independence Metropolis-Hastings (iMH) algorithm is used to sample from the posterior distributions of the random effects, since its proposal distribution does not depend on the current state of the parameter, which will become important. Choosing the iMH algorithm raises the issue of formulating an efficient proposal distribution for each of the n random effects, a problem that has not been solved in general. In this presentation, a general procedure is presented that automatically generates more efficient proposal distributions for each of the random effects' posterior distributions, as the number of effects (n) increase (i.e. the procedure scales). Another convenient feature is that the algorithm allows for parallel processing due to the structure of sampling problem (posterior distribution factors) and the use of the iMH algorithm. We illustrate our approach with sampling from the posterior ability distributions in the context of item response theory models, of which we usually have many.